Downstream Processing Market Players: GE Healthcare, Danaher Corporation, Repligen, And 3M Company

 Downstream Processing Industry Overview

The global downstream processing market size is expected to reach USD 94.8 billion by 2030, according to a new report by Grand View Research, Inc. The market is expected to expand at a CAGR of 15.0% from 2022 to 2030. The capacity requirements during the development of biologic drugs have changed over the past few years, wherein the demand for manufacturing high-volume products has shifted to developing small-volume, high-potency products. This creates new avenues for single-use technologies. A rise in the utilization of downstream processing techniques for the development of COVID-19 vaccines is a significant factor driving the market. The adoption of small-scale, single-use systems for process development and downstream processing is already high.

 

Thus, evolutionary changes are expected in the area of single-use technologies for manufacturing small-volume, highly-potent drugs. The development of novel film chemistries, closed systems, automation in clinical-scale single-use systems, and smart sensors are some noteworthy advancements in the field. A rise in applications of downstream processing for the production of biopharmaceuticals is expected to bring growth opportunities to the market. This has also led to an increase in strategic deals and development in the market. For instance, in February 2021, Evozyne, LLC collaborated with a leading rare disorders drug manufacturer for the production and marketing of novel biopharmaceuticals for immune modulation.

Downstream Processing Market Segmentation

Grand View Research has segmented the global downstream processing market based on product, technique, application, and region:

Based on the Product Insights, the market is segmented into Chromatography Systems, Filters, Evaporators, Centrifuges, Dryers, and Others.

  • The chromatography systems segment dominated the market and accounted for the largest revenue share of 41.7% in 2021. Continuous R&D activities to improve the efficiency and speed of chromatography systems are anticipated to propel segment growth. In April 2021, Thermo Fisher Scientific launched the HyPeak chromatography system, it is the company’s only single-use chromatography system for bioprocessing, with significant functions in therapeutic protein as well as vaccine development. 
  • The filters segment is expected to register the fastest CAGR from 2022 to 2030. A rise in the utility of filters for viral inactivation is the key factor driving the market for downstream processing. In September 2020, a team of researchers from the Pennsylvania State University analyzed the efficiency of BioEX hollow fiber and Planova 20N virus filters for the removal of viral-size particles. Such studies are anticipated to increase the adoption rate of filters for downstream processing of biologics.

 

Based on the Technique Insights, the market is segmented into Cell Disruption, Solid-liquid separation, Concentration, Purification by Chromatography, and Formulation.

  • The purification by chromatography segment dominated the global market and accounted for the largest revenue share of more than 41.00% in 2021. Single-use chromatography and filtration systems are considered the gold standards in downstream bioprocessing, hence companies are engaging in business development strategies, such as acquisition, merger, and agreement, for expanding their chromatography portfolio. For instance, in December 2021, Repligen bought Newton, New Jersey-based BioFlex Solutions.
  • The solid-liquid separation segment is expected to witness the highest CAGR during the forecast period. There are several advantages of solid-liquid separation, such as it is simple, cost-effective, and well suited for continuous-mode manufacturing. However, high shear forces generated are a common hurdle with this technique.

 

Based on the Application Insights, the market is segmented into Antibiotic Production, Hormone Production, Antibodies Production, Enzyme Production, and Vaccine Production.

  • The antibioticproduction application segment dominated the market in 2021 and accounted for the largest share of more than 32.5% of the global revenue. This high growth can be attributed to the wide application scope of antibiotics for the treatment of several disorders. More than 700,000 people die of antibiotic-resistant bacteria, annually. This leads to the high demand for the development of antibiotics, which in turn propels market growth.
  • Antibodies production grew at the fastest rate owing to the rise in demand for monoclonal antibodies. The launch of novel products for efficient purification of antibodies also propels segment growth. For instance, in January 2021, Cytiva launched HiScreen Fibro PrismA for the process development and purification of monoclonal antibodies (mAb). The product features a fiber-based Protein A platform which enables a 20-fold increase in productivity.

 

Downstream Processing Regional Outlook

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East & Africa (MEA)

 

Key Companies Profile & Market Share Insights

Companies are increasingly focusing on the development of new products for downstream processing. For instance, in April 2022, Merck entered a partnership with the administrative management Board at the Wuxi National High-Tech Industrial Development Zone. To considerably enlarge Merck’s premier Mobius a Single-Use production center in China. In February 2022, Sartorius completed its purchase of Novasep’s chromatography section. The portfolio bought includes chromatography systems designed largely for smaller biomolecules like peptides, oligonucleotides, and insulin, as well as new technologies for biologics’ continuous production. Some of the prominent players in the downstream processing market include:

  • Merck KGaA
  • Sartorius Stedim Biotech S.A
  • GE Healthcare
  • Thermo Fisher Scientific Inc.
  • Danaher Corporation
  • Repligen
  • 3M Company
  • Boehringer Ingelheim International GmbH
  • Corning Corporation
  • Lonza Group Ltd
  • Dover Corporation
  • Ashai Kasei
  • Ferner PLC
  • Eppendorf A

 

Order a free sample PDF of the Downstream Processing Market Intelligence Study, published by Grand View Research.

 

About Grand View Research

Grand View Research, U.S.-based market research and consulting company, provides syndicated as well as customized research reports and consulting services. Registered in California and headquartered in San Francisco, the company comprises over 425 analysts and consultants, adding more than 1200 market research reports to its vast database each year. These reports offer in-depth analysis on 46 industries across 25 major countries worldwide. With the help of an interactive market intelligence platform, Grand View Research Helps Fortune 500 companies and renowned academic institutes understand the global and regional business environment and gauge the opportunities that lie ahead.

 

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